|
KMID : 0355820160370010017
|
|
Korean Journal of Oral Anatomy
2016 Volume.37 No. 1 p.17 ~ p.25
|
|
|
The roles of vesicular glutamate transporters in somatosensory neurons
|
|
Kim Yun-Sook
Bae Yong-Chul
|
|
|
Abstract
|
|
|
|
Glutamate is an important neurotransmitter in the central and peripheral system. The vesicular glutamate transporters (VGLUTs) are involved in the active loading of glutamate into synaptic vesicles before exocytotic release and play an important role in glutamate signaling. There are three isoforms of VGLUTs. VGLUT1 and VGLUT2 are distributed by functionally-distinct subsets of primary sensory neurons: i.e., VGLUT1 is ex?pressed by mostly A(3 mechanoreceptive neurons and VGLUT2 by nociceptive neurons. VGLUT3 is expressed in the C-low threshold mechanoreceptor. However, VGLUT2-dependant glutamate release from primary sen?sory afferents plays an important role in acute and inflammatory pain, there is little information on the roles of VGLUT1 and VGLUT3 in the pathologic condition. We here review recently published papers in our and others groups showing that VGLUTs-mediated no?ciceptive informtion is mediated via specific primary afferent fibers and is processed in a distinct manner and differently in the somatosensory system; it provides us with useful information to better understand processing mechanisms of pain hypersensitivity in the orofacial region.
|
|
|
KEYWORD
|
|
|
trigeminal ganglion, pain, glutamate
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
|